研究方向
官方确认其研究长期聚焦遗传性出血性疾病、血小板生物学、基因组学和血液疾病。
pi-jorge-di-paola-versiti-mcw · evt-jorge-di-paola-versiti-mcw-2026-10
Jorge Di Paola
confirmedno recorded conflicts
- 职位
- Executive Vice President and Chief Scientific Officer; Associate Dean of Research; Professor of Pediatrics
- 学校
- Versiti Blood Research Institute / Medical College of Wisconsin
- 院系
- Versiti Blood Research Institute
- 州
- WI
- New PI / Verification
- incoming_new_pi
- 展示状态
- main
- 研究状态
- complete
- 优先级
- 57 / medium
研究概览
Jorge Di Paola 的研究主线高度集中在出血与血栓、血小板生物学及其基因组基础。近五年论文把患者队列、多组学、基因编辑细胞模型和体内外血栓实验连接起来；其即将承担的 VBRI 职责还包含机构级研究战略领导，但新的个人实验室项目尚未公开。
研究方向 6
研究方向
von Willebrand 病及 Zimmerman Program 是其与 Versiti 长期合作中明确可核验的研究轴。
依据
研究方向
2026 年 10 月起的 VBRI 职责包含领导研究所科学战略和转化研究增长；这是机构级职责，不等同于已公开的个人实验室项目。
依据
研究方向
近五年代表论文覆盖血小板基因变异的功能验证、血小板活化和血栓形成机制。
依据
- Functional classification of platelet gene variants using CRISPR HDR in CD34(+) cell-derived megakaryocytes.
- iMer, a naturally occurring MERTK splice variant, binds to GAS6 to decrease platelet activation and thrombus formation.
- N-Acetyl Cysteine Prevents Arterial Thrombosis in a Dose-Dependent Manner In Vitro and in Mice.
研究方向
多组学与代谢分析被用于解释骨髓增殖性肿瘤中的血小板异常和炎症。
依据
研究方向
大队列基因组研究持续关注 von Willebrand 病的结构变异与疾病分型。
依据
代表论文 5
Functional classification of platelet gene variants using CRISPR HDR in CD34(+) cell-derived megakaryocytes.
入选理由：代表血小板基因变异的 CRISPR 功能验证和巨核细胞模型。
iMer, a naturally occurring MERTK splice variant, binds to GAS6 to decrease platelet activation and thrombus formation.
入选理由：代表血小板活化和血栓形成的分子机制研究。
Multiomic profiling reveals metabolic alterations mediating aberrant platelet activity and inflammation in myeloproliferative neoplasms.
入选理由：代表多组学解析骨髓增殖性肿瘤中的异常血小板和炎症。
N-Acetyl Cysteine Prevents Arterial Thrombosis in a Dose-Dependent Manner In Vitro and in Mice.
入选理由：代表体外和小鼠动脉血栓模型中的干预研究。
Characterization of copy-number variants in a large cohort of patients with von Willebrand disease reveals a relationship between disrupted regions and disease type.
入选理由：代表 von Willebrand 病患者队列中的拷贝数变异研究。
RWD 产品匹配 3
通用仪器候选
全部需要人工验证不是已验证需求。 当前证据只说明研究领域、样本或一般实验背景相关，未确认该实验室实际使用或需要这些设备。
离心机
需人工验证 · 非已验证需求- 匹配类型
- 通用仪器候选
- 适配度分数
- 30
- 匹配理由
- 通用仪器候选（非已验证需求）。通过离心完成生物样本分离与制备。；上游证据仅支持相关研究领域或样本背景，未确认该实验室实际使用此工作流或设备。需在销售开发前人工核验。
- 人工确认
- 需要人工验证，不是已验证需求
- 匹配依据
- Jorge Di Paola, MD, to Lead Versiti Blood Research Institute as EVP and Chief Scientific Officer
- Multiomic profiling reveals metabolic alterations mediating aberrant platelet activity and inflammation in myeloproliferative neoplasms.
- Characterization of copy-number variants in a large cohort of patients with von Willebrand disease reveals a relationship between disrupted regions and disease type.
- N-Acetyl Cysteine Prevents Arterial Thrombosis in a Dose-Dependent Manner In Vitro and in Mice.
- iMer, a naturally occurring MERTK splice variant, binds to GAS6 to decrease platelet activation and thrombus formation.
- Functional classification of platelet gene variants using CRISPR HDR in CD34(+) cell-derived megakaryocytes.
PCR仪
需人工验证 · 非已验证需求- 匹配类型
- 通用仪器候选
- 适配度分数
- 30
- 匹配理由
- 通用仪器候选（非已验证需求）。用于梯度PCR和核酸扩增。；上游证据仅支持相关研究领域或样本背景，未确认该实验室实际使用此工作流或设备。需在销售开发前人工核验。
- 人工确认
- 需要人工验证，不是已验证需求
- 匹配依据
- Jorge Di Paola, MD, to Lead Versiti Blood Research Institute as EVP and Chief Scientific Officer
- Multiomic profiling reveals metabolic alterations mediating aberrant platelet activity and inflammation in myeloproliferative neoplasms.
- Characterization of copy-number variants in a large cohort of patients with von Willebrand disease reveals a relationship between disrupted regions and disease type.
- iMer, a naturally occurring MERTK splice variant, binds to GAS6 to decrease platelet activation and thrombus formation.
- Functional classification of platelet gene variants using CRISPR HDR in CD34(+) cell-derived megakaryocytes.
细胞计数
需人工验证 · 非已验证需求- 匹配类型
- 通用仪器候选
- 适配度分数
- 30
- 匹配理由
- 通用仪器候选（非已验证需求）。进行快速细胞计数和荧光分析。；上游证据仅支持相关研究领域或样本背景，未确认该实验室实际使用此工作流或设备。需在销售开发前人工核验。
- 人工确认
- 需要人工验证，不是已验证需求
- 匹配依据
- Jorge Di Paola, MD, to Lead Versiti Blood Research Institute as EVP and Chief Scientific Officer
- Multiomic profiling reveals metabolic alterations mediating aberrant platelet activity and inflammation in myeloproliferative neoplasms.
- Characterization of copy-number variants in a large cohort of patients with von Willebrand disease reveals a relationship between disrupted regions and disease type.
- N-Acetyl Cysteine Prevents Arterial Thrombosis in a Dose-Dependent Manner In Vitro and in Mice.
- iMer, a naturally occurring MERTK splice variant, binds to GAS6 to decrease platelet activation and thrombus formation.
- Functional classification of platelet gene variants using CRISPR HDR in CD34(+) cell-derived megakaryocytes.
冲突与不确定性
- 该任命于 2026-10-01 生效；当前分析不把机构级领导职责推断为已确定的个人实验室项目或采购需求。
关键链接
Published 2026-08-21T03:09:27.204147+00:00 · website-read-model/1.1